Hematological Studies on Rabbits in Experimental Inoculation of Influenza Virus.

Abstract

The leucocyte count of peripheral blood was investigated in experimental inoculation (rabbits) of the influenza virus, ultra-centrifuged influenza virus, formalininactivated influenza virus, influenza vaccine, alantoic fluid, added merthiolate and formaline to physiological saline solution. The results were as follows:
1) Decrease in leucocyte count was observed in rabbits after the injection, presumably by a substance which was produced in rabbits by influenza virus, but not directly by the virus.
2) Leucocyte count showed no change after the inoculation of influenza vaccine.
3) In the early stage of virus inoculation, leucocyte count decreased, then increased temporally and decreased again.
4) When the virus was given to the rabbits with hemagglutinin titer under 2⁵, leucocyte count demonstrated no change. The leucocyte count decreased, however, when the virus was inocultated to the rabbits with the titer over 2⁶.