Studies on the Influence of Cortisone on Candida Infection by Means of Embryonated Hen Egg

Abstract

Influence of Cortisone on C. albicans infection was investigated inoculating the organisms on allantoic membrane of embryonated hen eggs (12th day of hatching). The results were as follows:
1) The mortality rate of embryo became higher as the result of cortisone as compared with the single inoculation of C. albicans.
2) The growth of embryo at the day of hatch proved to be poor in the group of combined cortisone use as compared to that of single inoculation.
3) The fluid amount of allantoic sac was found less abundant in the group of C. albicans-single inoculation and in that of combined inoculation of Candida and cortisone than in the contrast group. In the group of cortisone single use the fluid amount demonstrated an increasing tendency.
4) No difference of the weight of heart, liver and kidney was recognized between the group of single inoculation and that of combined cortisone use.
5) The rate of positive culture of Candida inoculated from the allantoic fluid, heart, liver and kidney was much higher at the day of hatch in the combined cortisone inoculation group than in the single inoculation group.
6) Pathological findings in the liver and kidney showed no significant difference between the two groups, demonstrating invasion of Candida inoculated in all the organs.