広域ペニシリン“Viccillin”による細菌性赤痢患者の治療経験

抄録

“Viccillin” is a new penicillin prepared from 6-aminopenicillanic acid. It is of special interest because it is acid-stable and is active against a wide range of Grampositive and Gram-negative bacteria.
Fifteen patients with bacillary dysentery were treated with Viccillin. In adult patients, 500mg of Viccillin was given every six hours for three days, in children 250mg or 125mg.
After administration of Viccillin, fever subsided within 24 hours, numbers of stools decreased markedly within 1-3 days, and character of stool recovered within 3-5 days. The dysentery bacilli disappeared soon after the beginning of treatment in the majority of patients, but only in one case, stool cultures remained positive for 7 days after the treatment.
Over than one week after the period when the treatment finished, reappearance of dysentery bacilli in stools were observed in three cases.
No side effects were observed, except one patient, who had rash after administration. of the drug.
By the sensitivity test against various strains of Shigella, Viccillin is sensitive, similarly to streptomycin, less than tetracycline and chloramphenicole. Cross resistance between Viccillin and these three antibiotic drugs is not found, therefore this new antibiotica will be expected to apply for treatment of cases infected by anibiotic-resistant Shigella strains.