Aminobenzylpenicillin (Viccillin) in Carrier State of Typhoid and Paratyphoid Baccilli

Abstract

One carrier of typhoid (April, 1963) and another of paratyphoid-A bacilli (August, 1963) were treated orally with aminobenzyl penicillin (AB-PC) 2 gm. daily in four divided doses for five days.
The pathogens in the feces remained negative from the third day of medication to the end of hospitalization.
In successive examinations of A, B and C bile for two weeks, the pathogens in the biles remained negative from the fifth day of medication (Case No.1, typhoid carrier) and from the third day (Case No.2, parrtyphoid-A carrier) to the end of hospitalization.
According to the plate method, the typhoid bacilli isolated were susceptible to less than 0.39 mcg/ml of AB-PC while the paratyphoid-A bacilli to 0.78 mcg/ml of the drug.
It was concluded from the above that AB-PC was worthy of trying with typhoid carriers.