1963 Volume 37 Issue 2 Pages 39-45
1) Resistant strains of dysentery bacilli to streptomycin, chloramphenicol and/or tetracycline increased in number rapidly from 1959. In 1960 21.8% of all the dysentery bacilli isolated in our clinic were antibiotic-resistant. They were divided clearly into two groups, sensitive and resistant. Intermediate strains were scarcely discovered. Dysentery bacilli tested by the authors were all sensitive to kanamycin, furaltadone and colistin. Most strains of dysentery bacilli were resistant to sulfadiazine, but a few remained sensitive.
2) Most strains of Sh.flex. were very sensitive to CHQ (chlorhydroxyquinoline)(minimal inhibitory concentration: 0.2-0.8 mcg/ml), whereas Sh. sonn., Sh.flex.4 and Sh. flex.6 were less sensitive (M.I.C.: 6.3-25 mcg/ml).
3) The concentration of CHQ in the intestinal tracts of mice was relatively high after the oral administration. Its concentration in other organs, however, such as liver, spleen, lung, kidney and blood, could not be demonstrated by the biological method used by the authors
4) Antibacterial activity of C.H.Q. was not influenced in liver tissues of mice.
5) In spite of ot the high “in vitro” susceptibility of dysentery bacilli to CHQ, they responded only poorly to the agent in vivo. In view of the serious problem of dysentery due to antibiotic-resistaut strains in Japan, however, CHQ might be considered as one of the available drugs. No side effects were seen after the oral administration.
