Antigen-Antibody Reaction on Cancer Toxin considered from the acting mechanism of the Microorganismic Anticancer

Preparations and the Anticancer Organ Ingredients

Abstract

The microorganismic anticancer preparations excluding antibiotics, and the anticancer organ ingredients may he classified as follows.
1) Streptococci (Ferment ction) 2) Purified small pox vaccine 3) Kruzin: prepared by Mrs. Klujewa in USSR. This is extracted from the Trypanosoma cruzi.
4) E.D Virus 5) Bacteria reparations (Serratia Marcesens) 6) γy-Globulin 7) Latent anticancer factor extracted by Nakahara and Fukuoka. This is contained in a normal mouse liver. 8) Antirabic vaccine.
Regarding the antirabic vaccine, De Pace recognized the fact that the cancer of uterine cervix had become small with the infections of this accine. Out of the above mentioned preparations, the author applied the antirabic vaccine, the suspension of streptococci, the emulsion of rabbit brain in which the cancer toxin B Substance was injected and adjuvant to the experimental animals (rabbits and mice), and the influence of those preparations to the cancer toxin and the extract of mouse spleen was examined from the viewpoint of the antigen-antibody reaction.
Out of 7 mice, hepatoma developed only in one mouse injected with the cancer toxin B substance. Such a hepatic cancer caused by the cancer toxin B Substance seemed to be the first example except the cancer producing xperiment by Grace with the use of extracted liquid from a human cancer.
The blood sera immunized with the ultravioletly inactivated antirabic vaccine were roved to show higher antibody titers for the antigens of the cancer toxin, the extract of mouse spleen and the streptococci.
Accordingly, the removal of brain substance from the vaccine seemed to be desirous because the higher titers for those antigens were assumed to be caused not by a immune response in the form of antigen-antibody reaction, but by a high ry-Globulinemia in hepatic lesion. Hereupon, Yoshino's chickembryo vaccine inactivated with 0-propio laction may be xpected as an useful anticancer preparation owing to the high immunogenity and the low content of brain substance. In this experiment, moreover, the antirabic accine was proved to possess an effect to increase number of leucocytes after the experiment in contrast to the antibiotics.
For the same reason as Yoshino's vaccine, the rinder pest active vaccine and the embryo vaccine for swine fever (cholera) were expected to be effective for malignant tumors. Trypanosoma has been said to contain trypanotoxin, antitoxin, complement conjugating antibody, hemolysin and so on at the same time, being very interesting from the immunoserological point of view.