The frequency of the biologic false-positive reaction (BFP) in patients with positive standard test for syphilis has been estimated to Le about 40 per cent by Moor. With the decline in cases of apparent syphilis, it is anticipated that there will be a relative increase in number difficult to make definite clinical diagnosis.
For the purpose of diminishing the BFP treponema or its specific antigen must be used in the test. D'Alessandro et al who investigated the antigenicity of various fractions of Treponema Reiter strain recommended the protein fraction as a specific antigen in complement fixation test for syphilis.
The present studies have been made to compare the diagnostic value of Reiter Protein Complement Fixation test (RPCF), VDRL-Slide test (VDRL-S), and cardiolipin Complement Fixation test (Cardio-R). The conclusion was as follows;
1) In series of 2077 serum specimens for syphilis serologic test, the percentage of agreement among RPCF, VDRL-S and Cardio-R was 92.44%, that of disagreement being 7.56%.
2) The RPCF test had a specificity of 93.42% in latent syphilis and 94.74% in congenital syphilis.
3) The BFP-like reaction of RPCF was observed in 8.62% in pregnancy, in 12.31% in tuberclosis and in 13.04% in cancer. Because of the paucity of the specimens, it was impossible to clarify whether these results were true BFP in each disease.
4) The relative sensitivity of the three tests was as follows: Positive rate was 99% for the VDRL-S test, 91.67% for the RPCF test and 92.86% for the Cardio-R (Ogata). There was no difference between RPCF test and Cardio-CF (Ogata).

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The microorganismic anticancer preparations excluding antibiotics, and the anticancer organ ingredients may he classified as follows.
1) Streptococci (Ferment ction) 2) Purified small pox vaccine 3) Kruzin: prepared by Mrs. Klujewa in USSR. This is extracted from the Trypanosoma cruzi.
4) E.D Virus 5) Bacteria reparations (Serratia Marcesens) 6) γy-Globulin 7) Latent anticancer factor extracted by Nakahara and Fukuoka. This is contained in a normal mouse liver. 8) Antirabic vaccine.
Regarding the antirabic vaccine, De Pace recognized the fact that the cancer of uterine cervix had become small with the infections of this accine. Out of the above mentioned preparations, the author applied the antirabic vaccine, the suspension of streptococci, the emulsion of rabbit brain in which the cancer toxin B Substance was injected and adjuvant to the experimental animals (rabbits and mice), and the influence of those preparations to the cancer toxin and the extract of mouse spleen was examined from the viewpoint of the antigen-antibody reaction.
Out of 7 mice, hepatoma developed only in one mouse injected with the cancer toxin B substance. Such a hepatic cancer caused by the cancer toxin B Substance seemed to be the first example except the cancer producing xperiment by Grace with the use of extracted liquid from a human cancer.
The blood sera immunized with the ultravioletly inactivated antirabic vaccine were roved to show higher antibody titers for the antigens of the cancer toxin, the extract of mouse spleen and the streptococci.
Accordingly, the removal of brain substance from the vaccine seemed to be desirous because the higher titers for those antigens were assumed to be caused not by a immune response in the form of antigen-antibody reaction, but by a high ry-Globulinemia in hepatic lesion. Hereupon, Yoshino's chickembryo vaccine inactivated with 0-propio laction may be xpected as an useful anticancer preparation owing to the high immunogenity and the low content of brain substance. In this experiment, moreover, the antirabic accine was proved to possess an effect to increase number of leucocytes after the experiment in contrast to the antibiotics.
For the same reason as Yoshino's vaccine, the rinder pest active vaccine and the embryo vaccine for swine fever (cholera) were expected to be effective for malignant tumors. Trypanosoma has been said to contain trypanotoxin, antitoxin, complement conjugating antibody, hemolysin and so on at the same time, being very interesting from the immunoserological point of view.

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Combined use of Kanamycin (KM) and chloramphenicol (CP) in equal dosis was applied to 31 cases of bacillary dysentery, of which 15 were resistant against commonly used broad spectrum antibotics, in order to investigate its clinical effects, development of antibiotic resistance and reappearance of bacilli in the stool in comparison with the separate use of KM and CP. Five hundred mg Kanaphenicol (KP) was given to adults every 6 hours for 4 days, the same in the alone use of KM and CP.
In in vitro use of KP, no significant synergistic effects were observed against CP-resistant and CP-sensitive strains except some additive ones.
KP was clinically effective in 86.7% of antibiotic-resistant cases, inducing subsidence of fever, decrease in number of stools, removal of tenesmus, disappearance of bacilli and recovery of stool nature, KM used alone being effective only in 56%. The rate of reappearance of bacilli was far less in KP as compared with KM. Against antibiotic-sensitive cases, however, KP was as effective as KM, i. e. in over 90%. Reappearance of resistant strains was seldom observed in KP-treated cases, whereas 3 out of 32 cases treated with KM acquired readily resistance. No side effects were found following KP treatment, except slight stomac ache and soft stools in a small number of cases.
It was revealed that combined use of KM and CP demonstrated better clinical effects against bacillary dysentery, particularly against antibiotic resistant cases, as was expected from in vitro experiments, though some problems such as reappearance of bacilli require fur-ther investigation.

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