1964 Volume 38 Issue 1 Pages 26-32
For the treatment with Colistin methansulfate 500-1, 000 mg daily, rapid disappearance of Dysentery bacilli was seen, however, improvement of clinical symtoms was not satisfactory and milder than that of CP or Tc. The authers presumed that the discrepancy of the effect between these drugs may be due to a difference of the mechanism of action of drugs.
For the improvement of the effect of Colistin, it would be emphasized to try a combined. treatment of this drug and another antibiotics like Cp, rather than to augment the dosis of Colistin