1966 Volume 39 Issue 10 Pages 359-365
Until now, most of the studies of infectious diseases have been foccused on the invading organism and antibiotics. The role of antibiotics can not be underestimated in decreasing the mortality rate of various infectious diseases.
The other factor which determines clinical course of infectious diseases has been known to be immunological response of the host, measured by circulating antibodies. However, because of the complex relationship of antibodies and antibiotics, conclusions drown from various observations have been controversial.
The purpose of this paper is to disclose immunological respons elicited by various septic diseases and thus the reactivity of host.
Animals periodicaly immunized with streptococcus sanguis, denatured auto-gamma-globulin and runted animals by spleen homogemate injection peritonealy were subjected ected to various laboratory tests. Total protein and gamma-globulin increased in these immunized animals at initial stage of the immunization (15-30 days) followed by a transient decrease. After this, gradual increase of them was noted during the continuous immunization (70-105 days). Anti-gamma-globulin (FII) antibody andantiliver antibody increased in their percentage as the immunization prolonged. Several characteristics of these gamma-globulins which occurred at the later stage of immunization strongly suggested that these antibodies developed against denatured auto-gamma-globulin or hepatic cells. On the toher hand, in runted animals, antibodies which usually developed at the later stage of immunization were detected at the early stage suggesting more strongly insulted host conditions. Survey of clinical cases from the standpoint of immune serology indicated complicated interrelationship of various factors such as age, sex and duration of the disease. A definite conclusion could not be obtained through above experimental and clinical observations to evaluate the role of immunological response of host of combat with invading organism in septic diseases, but we are convinced that in near future this would be an important factor besides antibiotics for controling infectious diseases.
