Until now, most of the studies of infectious diseases have been foccused on the invading organism and antibiotics. The role of antibiotics can not be underestimated in decreasing the mortality rate of various infectious diseases.
The other factor which determines clinical course of infectious diseases has been known to be immunological response of the host, measured by circulating antibodies. However, because of the complex relationship of antibodies and antibiotics, conclusions drown from various observations have been controversial.
The purpose of this paper is to disclose immunological respons elicited by various septic diseases and thus the reactivity of host.
Animals periodicaly immunized with streptococcus sanguis, denatured auto-gamma-globulin and runted animals by spleen homogemate injection peritonealy were subjected ected to various laboratory tests. Total protein and gamma-globulin increased in these immunized animals at initial stage of the immunization (15-30 days) followed by a transient decrease. After this, gradual increase of them was noted during the continuous immunization (70-105 days). Anti-gamma-globulin (FII) antibody andantiliver antibody increased in their percentage as the immunization prolonged. Several characteristics of these gamma-globulins which occurred at the later stage of immunization strongly suggested that these antibodies developed against denatured auto-gamma-globulin or hepatic cells. On the toher hand, in runted animals, antibodies which usually developed at the later stage of immunization were detected at the early stage suggesting more strongly insulted host conditions. Survey of clinical cases from the standpoint of immune serology indicated complicated interrelationship of various factors such as age, sex and duration of the disease. A definite conclusion could not be obtained through above experimental and clinical observations to evaluate the role of immunological response of host of combat with invading organism in septic diseases, but we are convinced that in near future this would be an important factor besides antibiotics for controling infectious diseases.

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1) A 35 aged housewife, 7 days after artificial abortion at 7th month of pregnancy, developed septicemia due to staphylococcus aureus. Clinical and autopsy findings were reported.
2) Autopsy revealed that the wound of endometrium was the cause of bacteremia.
3) X-ray findings of hematogenic lung abscesses had the similarity to that of malignant chorion epithelioma. It was stressed by the authors therefore that the differencial diagnosis, especially the test of pregnancy must be carried out carefully in pregnant and puerperal stage.
4) The fatal acute renal failure took place in the course of bacteremia. Histopathological study of kidney showed considerable amount of edema and round cell infiltration in the interstitial space and degeneration of tubular cell and minimum change of glomeruli. Most suitable name of diagnosis would be acute interstitial nephritis

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The pathogenicity of Pseudomonas aeruginosa (abbreviated as Ps) strains, when isolated from a sterile cavity or organ, can be easily decided. But it is not the case when the Ps strains are isolated concomitantly with other microganisms. In the latter cases it may be possible to estimate the pathogenicity of the isolated Ps stains by the titration of antibody to Ps in the serum of patients.
From this point of view, we tried the determination of antibody in the sera of normal adults, Ps carriers in the sputa and the patients with Ps strains of clear pathogenicity. We used the bacterial aggulutination test, the simplest serological technique. The living bacterial cells of the Ps strain DK 160, DK 161 and DK 163 were used as the antigen and the results were as follows:
1.0 agglutinin titer of the sera of normal adults was 1: 80 or less than 1: 80.
2) 0 agglutinin titer of the Ps carriers was also the same as that of normal adults.
3) When the serum of a patient shows the agglutinin titer of 1: 160 or more then 1: 160, it may serologically be suggested that the patient is suffering from Ps infection.

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