Field Trials of Live Influenza Vaccine Carried out from December 1962 to February 1963.

Abstract

Mass vaccination of live influenza vaccine produced in our laboratory was carried out in Osaka from December 1962 to February 1963. Febrile reactions were observed in 1.5% out of 1, 818 adults and in 1.4% out of 1, 220 children. Persons needed to stay .away from work or school were 1.1% and 0.6% respectively. Mean incubation period and duration of clinical reactions were 12 hours or less. No remarkable difference in clinical reactions was observed between the persons over 10 years and those under 10 years. Some clinical reactions were also observed in the persons with placebo vaccine, and no remarkable differences were.observed between placebo and A2 or B type vaccine. Four fold or more HI antibody rise against influenza A2 virus was observed in 60% out of 57 adults and in 68%. out of 25 children. No difference in antibody response was observed between the persons with and-those without clinical reactions