Journal of the Japanese Association for Infectious Diseases

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In February 1961, there was an outbreak of Izumi-fever in a school which was located in suburb of Tokyo.
Sixty nine (11.2%) of 52.3 girls aged 12 to 20 were involved, and 40 of them, boarding pupils, were carefully observed in dedails.
Main symptoms were fever, rash in fine erythematous form, headache, backache, lumbar pain, anorexia and abdiminal pain. There were no pharyngial findings and tonsillitis except two cases.
In most cases slight strowberry tangue was found on the tip, and abdominal pain has lasted far over 2 weeks. It was remarkable that nodural erythema appeared on the 8th to 25th day of the disaease in 8 cases, persisting for. 2 to 15 days.
Chloramphenicol and Tetracycline appeared to be effective especially to make the febrile period shorter.
The mode of communication was suspected to be of oral route.
Two causative viral agents were isolated from bloods of three patients by Dr. Kasahara and his co-workers in Kitasato Institute.

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Mass vaccination of live influenza vaccine produced in our laboratory was carried out in Osaka from December 1962 to February 1963. Febrile reactions were observed in 1.5% out of 1, 818 adults and in 1.4% out of 1, 220 children. Persons needed to stay .away from work or school were 1.1% and 0.6% respectively. Mean incubation period and duration of clinical reactions were 12 hours or less. No remarkable difference in clinical reactions was observed between the persons over 10 years and those under 10 years. Some clinical reactions were also observed in the persons with placebo vaccine, and no remarkable differences were.observed between placebo and A2 or B type vaccine. Four fold or more HI antibody rise against influenza A2 virus was observed in 60% out of 57 adults and in 68%. out of 25 children. No difference in antibody response was observed between the persons with and-those without clinical reactions

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