Clinical and Drug-Sensitivity Observations on Bacillary Dysentery Cases Treated in Jonan Hospital in 1964

Abstract

1) The results were as follows
1) Among 214 strains (77.2% of 277 cases admitted) isolated, 185 (86.4%) strains of Shigella Sonnei were found. Among 150 antibiotic resistant strains 143 were resistant against 3 drugs (Streptomycin, Tetracycline, Chloramphenicol).
The rate of antibiotic resistance of the strains isolated from sporadic dysentery cases was 63.9%.
2) 164 (59.2%) cases of mass incidences of bacillary dysentery were admitted in our hospital at all seasons of the year, exceeding in number sporadic cases.
The bacillary type of a mass incidence was 3-drugs-resistant Shigella Sonnei in 3 of 4 cases. One case was caused by a mixed infection of antibiotic-sensitive and-resistant strains.
3) The body temperature of about half the cases admitted was above 39 C but we found recently mild bacillary dysentery cases due to the administration of antibiotics before hospitalization.
4) Sodium Colistin Methanesulfonate (COM) combined with Kanamycin demonstrated therape utic effects against dysentery caused by antibiotic resistant strains.
5) Triacetyloleandomycin and Erythromycin were effective in clinical_ use in spite of a low sensitivity in vitro, but the mechanism is unclear.
6) COM and Kanamycin were sensitive against 3-drygs-resistant strains, and no cross resistance with SM, CP and TC was seen.
Sensitivity of KM ranged from 3.12 mcg/ml to 25 mcg/ml, and that of COM ranged from 1.56 mcg/ ml to 12.5 mcg/ml.
Against 3-drugs-resistant strains in vitro, chlotaon demonstrated therapeutic effects in clinical use.
Nalidixic Acid was sensitive against 3-drugs-sensitive and 3-drugs-resistant strains.
Sensitivity of drysentery bacilli against Nalidixic Acid ranged from 3.12 mcg/ml to 12.5 mcg/ml.