Studies on the Serologic Epidemiology of Aseptic Meningitis

Abstract

From the reason that the outbreaks of viral meningitis due to enterovirus were recently experienced in Japan, the invasion grade of ECHO 4, 6, 9, 12, 14, 30 and Coxsackie A9, B3, B5 in Fukuoka Prefecture was studied by the author with the following methods.
The antibody possessing ratio in each age group against ECHO 4, 6, 9, 12, 14, 30 and Coxsackie A9, B3, B5 was tested by monkey kidney cell culture using the 4-fold dilution of serum The sera uere obtained from 4, 800 healthy people during October of 1963 to October of 1965. The pattern of every type reflected their epidemiologic and ecologic characteristics.
From these results, ECHO 14, Coxsackie B5 and Coxsackie A9 virus are regarded as widespread virus, ECHO 6, 9 and Coxsackie B3 virus are regarded as narrow-spread virus. Coxsackie B5, ECHO 12 and ECHO 30 virus infections may occur epidemically.
Therefore it is desirable that serological examination should be made in order to estimate the epidemiology of viral meningitis.