On dysentery, it has been seen that the condition of the bacteria in the intestine are quitemuch changed than usual. In this situation, administration of Str. fecalis may convert it normal, however the antibiotic treatment to the dysentery also remove the administered Str. fecalis p.o. So, the author set up the multiple drug resistant Str. fecalis and it was administered to dysenterypatient p.o. On examination, the presence of Str. fecalis was proved in the stool of dysenterypatient who were having antibiotic treatment.

View full abstract

From the reason that the outbreaks of viral meningitis due to enterovirus were recently experienced in Japan, the invasion grade of ECHO 4, 6, 9, 12, 14, 30 and Coxsackie A9, B3, B5 in Fukuoka Prefecture was studied by the author with the following methods.
The antibody possessing ratio in each age group against ECHO 4, 6, 9, 12, 14, 30 and Coxsackie A9, B3, B5 was tested by monkey kidney cell culture using the 4-fold dilution of serum The sera uere obtained from 4, 800 healthy people during October of 1963 to October of 1965. The pattern of every type reflected their epidemiologic and ecologic characteristics.
From these results, ECHO 14, Coxsackie B5 and Coxsackie A9 virus are regarded as widespread virus, ECHO 6, 9 and Coxsackie B3 virus are regarded as narrow-spread virus. Coxsackie B5, ECHO 12 and ECHO 30 virus infections may occur epidemically.
Therefore it is desirable that serological examination should be made in order to estimate the epidemiology of viral meningitis.

View full abstract

Few reports on the relationship between bacteriological findings of stools and clinical symptoms in diarrheal patients are available at the present time.
So, bacteriological examinations on 429 diarrheal patients were carried out in a hospital of Tochigi prefecture for 12 months (from Nov. 1964 to Nov. 1965) and its relations with clinical symptoms were analyzed in this paper.
Though dysentery is said to have recently been attenuated considerably, general impression through this servey is that the symptoms such as fever, frequency of stool and nature of stool were still severer in dysentery than in simple diarrheal patients (including the patients discharging pathogenic E. coli).
According to the criterion set up for classification of severity of dysentery by Takigami (1965), dysentery patients were divided into such three groups as 1) mild 2) moderate 3) severe, and percentage of it is 1) 44.9% 2) 40.6% 3) 14.4%, respectively. It can be said from these data the serious cases are really declining in dysentery nowadays.
However, the fact that the number of severe cases were as low as 1.6% in simple diarrheal patients, and still as high as about 15% in dysentery should be kept in mind.
It is worthy of describing that the fever was only a recognizable but prevailing symptom except diarrhea in the patients discharging pathogenic E. coli, and isolation of this bacilli was highest in severe group of simple diarrheal patients.
In dysentery, quite understandably, isolation rate of dysentery bacilli was related with the nature of stool; the more the stool findings deteriorated the more increased the isolation rate. Unlike dysentery bacilli, isolation rate of pathogenic E. coli had no relation with the nature of stool.
To speak generally, the more the nature of stool deteriorated, the more thrived klebsiella and proteus, the less E. coli.

View full abstract

The drugs used for sensitivity test were sulfonamide (SA), streptomycin (SM), chloramphenicol (CM), tetracycline (TC) and kanamycin (KM). The same 429 patients as used in prior report 1., 100 healthy persons and 47 new borns, and their stools were subjected to this study.
In 302 patients under 14 years of age, shigella was isolated from 53 patients (17.6%) and pathogenic E. coli, from 12 (4 %). In 127 above 15 years of age, shigella was isolated from 16 (12.6%), pathogenic E. coli, from 5 (3.7%) and vibrio parahaemolyticus, from 2 (1.6%).
Frequency of drug resistant enteric bacteria (including non-pathogenic bacteria) was 35.2% in diarrheal patients and 11%, in control (healthy persons).
More than 20% of E. coli and shigella isolated from diarrheal patients were proved to be multiple drug resistant (SM. CM. TC), 18% of citrobacter and 14% of enterobacter were resistant to (SM) alone. The bacilli other than above mentioned were less frequently drug resistant
(below 10%). Klebsiella group were far less frequently drug resistant (3-4%).
As to the multiplicity of drug in drug resistance, four drugs pattern (SA·ESM·ECM·ETC) was most frequently encountered, followed by three (SA·ESM·ECM) and two (SA·ESM), rarely including (KM). Various drug patterns of drug resistance were seen in E. coli. A strain of citrobacter was found resistant against five drugs (SA·SM·CM·TC·KM), a strain of E. coli and enterobacter, against four drugs (SA · SM · TC · KM) and a strain of citrobacter, against three drugs (SA·ESM.KM).

View full abstract