わが国における風疹の血清疫学的調査研究

第2報 東京都一般住民の中和抗体保有状況並に風疹流行後に観察された都内某中学校学童の中和抗体の変動について

抄録

As the second report of this series, the authors presented the results of two surveys:(a) Between. March and August in 1966, a total of 170 persons among residents of Tokyo city were examined for possessing rate of positive neutralizing antibody to rubella virus mainly by age distribution and sex. (b) Incidentally, the authors had a chance to survey the antibody of school children of a junior high school in Tokyo city which reportedly had experienced in spring in that year, about one month previously to the survey, a rubella epidemic of limited size, involving, however, more or less almost whole classes of that school.
The both were summarized as follows:
1. In the survey (a), the possessing rate in age group of 0-4 was about 10%, began to increase at 5-9 years of age, and reached the maximum (almost 100%) at 20-24. This pattern is similar to reported. data about the antibody on inhabitants of large cities such as Osaka and New York. This suggests that rubella epidemics of considerable size have been attacking the city residents every year.
Any appreciable difference in the possessing rate by sex did not occur to any age group, as was the case in Kumamoto city.
2. In the survey (b), possessing rate of the antibody in such a school class as involving only a few manifesting patients remained at around 60% at the highest, the figure being close to the average of citydwellers tested in the survey (a) of corresponding age. On the other hand, in a class where a considerable proportion had manifested, the rate rose up to over 80%. These findings should be an implication. of the necessity of heavy contacts for the transmission of the infection.
Some discrepancy existed between the outcome of serological tests and questionaire data. This indicates a considerable portion of non-manifesting infections in this epidemic and confirms the necessity of neutralizing antibody tests for the final diagnosis of this disease.