Enhancement of Antimicrobial Defense Activities of Immunoglobulins in Lung

Abstract

We studied the effect of immunoglobulins (monomeric IgG, monomeric IgA, secretoryIgA) and bronchoalveolar lavage on the bactericidal activity by neutrophils. Results are as follows
1. Escherichia coli (E.coli) was killed by secretory IgA, and E. coli was more killed by secretory IgA with neutrophils.
2. Bronchoalveolar lavage enhanced the bactericidal activity by neutrophils less than fresh plasma.
3. Secretory IgA or monomeric IgA enhanced the bactericidal activity by neutrophils with bronchoalveolar levage.