Abstract
In an attempt to suppress fecal flora in patient with hematological disease increasing incidence of infection, prophylactic nonabsorbable antibiotic regimen was carried out in ten patients.Ten patients were eight with acute leukemia admitted for remission induction and two with allogeneous bone marrow transplantation for severe aplastic anemia.The oral antibiotic regimen consisted of Tobramycin 720 mg/day, Vancomycin 1500 mg/day and Nystatin 300×104units/day (TVN regimen).The results were obtained as follow:
1) Fecal flora was completely suppressed (undering 1×102 bacteria per 1 g feces) 2 weeks after initiation of TVN regimen.Suppression of fecal flora remained for the following 4 weeks at least.
2) Suppression of anaerobic fecal flora showed a tendency to be delayed in comparison with suppression of aerobic fecal flora.
3) Administration of TVN three times a day could suppress fecal flora.
4) During administration of TVN, Candida speicies were detected in 7 patients.
5) Concentration of Tobramycin and Vancomycin in serum, urine and feces after administration of TVN regimen were investigated.As a result, absorption of antibiotics from the intestines was a very small amount.
As mentioned above, fecal flora was completely suppressed after administration of TVN, but suppression of fungous fecal flora was unsatisfactory.Therefore, TVN regimen was thought to matter suppression of fungous fecal flora for the future.
