An Interleukin-1 Inhibitor in the Urine of Febrile Patients

Abstract

Urine from febrile patients were shown to contain an interleukin-1 (IL-1) inhibitor when tested on IL-1 induced proliferation of C3H/HeJ mice thymocytes. This IL-1 inhibitor was not cytotoxic for mice thymocytes and approximate m.w. of this activity was 20000 to 50000. Presence of this IL-1 inhibitor may be important in the regulation of IL-1 enhanced inflammatory response.