1988 Volume 62 Issue 6 Pages 551-556
Pneumocystis carinii pneumonia (PCP) is a well known opportunistic infection in HIV-infected patients.
Trimethoprim-sulfamethoxazole (S-T combination) and pentamidine are recommended for the treatment of PCP. Since 1985 we have treated 6 HIV-infected patients with S-T combination. Three patients revealed drug eruption, fever and impaired liver function during the course of the treatment. Two of the 3 patients had to have their treatment were discontinued and one was switched to pentamidine administration for PCP successfully despited the serious side effects.
In this report we discussed the incidence of the adverse reaction of S-T combination and pentamidine, as well as evaluating these two preparations for the treatment of PCP in HIV-infected patients.
