1988 Volume 62 Issue 6 Pages 608-612
A female patient received an exchange transfusion for ABO maternal incompatibility, when she was a newborn infant. We speculate that she became an HBsAg carrier in this manner, because there were no HBsAg carriers in her familiy. When she was 16 years old, it was detected that she was suffering from chronic active hepatitis by biopsy and that her serum was positive for HBsAg, anti- HBc, and anti-HBe, but not for HBeAg. When she was 19 years old, HBsAg was eliminated from her blood and anti-HBc became low grade. Although at 22 years of age, anti-HBs appeared in her blood, serum transaminase levels were elevated. Generally, when HBsAg was eliminated in chronic hepatitis, hepatitis did not get worse, however, at the age of 26 years she was diagnosed as having liver cirrhosis with esophageal varices. Moreover, it was found that she had proteinuria and microscopic hematuria. It was also proved by biopsy that she had a complication of hepatic glomerulosclerosis. This was a rare case became the elimination of HBsAg occurred before 20 years of age.
