A case of autoimmune hepatitis with severe liver fibrosis who was effectively treated with long-term administration of cyclosporin, leading to marked improvement of liver fibrosis

Abstract

Summary: A 61-year old woman, who was diagnosed as autoimmune hepatitis with severe liver fibrosis had been treated with prednisolone and ursodeoxycholic acid, was referred to our hospital due to repeated aggravation. After administration of cyclosporin, serum aminotransferase was normalized. Liver fibrosis, which was corresponded to cirrhosis at first, was significantly improved 3.5 years after cyclosporin treatment, followed by further improvement to F2 after 6.5 years. Now, she remains stable clinical presentation by continuing therapy with cyclosporin for over 7.5 years.