A case of resection of hepatocellular carcinoma associated with primary biliary cirrhosis (PBC) who had prior infection with HBV

Abstract

A 78-year-old man who had been treated for primary biliary cirrhosis (PBC) for approximately 10 years developed hepatocellular carcinoma (HCC). Serological findings suggested that he had a prior infection with HBV. The patient underwent resection of the S4 segment. Resected tumor tissue showed poorly differentiated HCC, and the adjacent liver tissue showed consistent with liver cirrhosis of PBC (Scheuer IV). To clarify the relation of prior infection with HBV, we performed Alu-PCR to detect viral- host junction, but we couldn't detect it. Since 1990, only 11 patients with HCC based on PBC underwent liver resection and this is the first case report investigating whether HBV-DNA integration occurs in HCC from PBC.