Abstract
In Japan the number of patients who are co-infected with hepatitis B and C virus is little. On the other hand there are many reports in the world that HBV reactivation often occur in the co-infected patients at the end of treatment or after IFN with ribavirin therapy. But the flare of hepatitis B is rare during combination therapy. In this case report, hepatitis B virus was reactivated and the flare happened in the middle of the therapy of IFNα2a with ribavirin, although HBV-DNA before treatment had been negative. To avoid the next flare entecavir was medicated. And then hepatitis B settled down. It suggests that entecavir would be effective if the flare of hepatitis B occurred.
