Abstract
We describe two cases of hepatocellular carcinoma (HCC), lung metastases of which showed remarkable spontaneous regression. Case 1 is a 65-year-old man who had repeatedly received therapy of transcatheter arterial chemoembolization (TACE) for his HCC. Nineteen months after the diagnosis of HCC, multiple lung metastases appeared. Two months after the start of best supportive care without any anti-cancer treatment, metastatic lesions of the lung almost completely disappeared. Case 2 is a 78-year-old female. She had received repeated therapy of TACE for her recurrent HCC subsequently to a hepatectomy. Five years after the first development of HCC, multiple lung metastases were detected. After six months of palliative care instead of anti-cancer treatment, lung metastases revealed remarkable regression. Although the mechanism of the spontaneous regression is unclear, case 1 had quit smoking and drinking followed by repeated medication of NSAIDs, and case 2 had kept eating health foods, after the diagnosis of their lung metastases.
