Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
Short Communications
Renal dysfunction with telaprevir in combination with peginterferon alfa-2b and ribavirin therapy
Itaru OzekiMutsuumi KimuraTomohiro ArakawaTomoaki NakajimaYasuaki KuwataTakumi OhmuraTakahiro SatoShuhei HigeYoshiyasu KarinoJoji Toyota
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2012 Volume 53 Issue 7 Pages 425-428

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Abstract
The purpose of this study is to investigate the effect of telaprevir based-regimen on the renal function of HCV patients. The telaprevir based-regimen caused a transient and reversible decrease in eGFR in patients (n=17) who were enrolled in a phase 3 trial in Japan. In addition, we examined the relationship between baseline characteristics and the renal function of patients (n=25) after marketting. Age was significantly related to the renal dysfunction. The present result indicates that the kidney function of aged patients including creatinine elevation is required to be careful monitored.
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© 2012 The Japan Society of Hepatology
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