Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
Studies on the mechanism of action of saikosaponin
3. Effects on microsomal enzymes
Hiroko ABETakaharu NAGAOShigeru ARICH
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1978 Volume 19 Issue 11 Pages 1058-1062

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Abstract
The activities of Glucose-6-phosphatase and NADPH-cytochrome c reductase of the rat liver which were treated with saikosaponin 2mgtkg or 20mg/kg of body weight were compared with that of a normal rat liver. The activities of Glucose-6-phosphatase and NADPHcytochrome c reductase of the liver homogenate of saikosaponin 2mg/kg injected rat were remarkably increased but these activities of the liver homogenate of saikosaponin 20mg/kg injected rat were not changed. In the smooth microsome isolated from the liver treated with saikosaponin 20mg/kg of body weight, NADPH-cytochrome c reductase activity was slightly increased, and the remarkable increase of Glucose-6-phosphatase activity of rough microsomes isolated form the liver treated with saikosaponin 2mg/kg of body weight was observed.
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© The Japan Society of Hepatology
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