1980 Volume 21 Issue 10 Pages 1310-1315
1) In the patients with HBs-antigen positive liver disease (82 cases) and asymptomatic carriers (16 cases), 24 cases (24.5%) were HBe-antigen positive, 65 cases (66.3%) were HBeantibody positive and nine cases (9.2%) were both negative.
2) In the subjects over forty years old (male 34 cases, female 16 cases), only two females (12.5%) were HBe-antigen positive, although nine cases (26.5%) in male.
3) In the cases with more than 29 of HBs-antigen titer (r-PHA), significantly more subjects were HBe-antigen positive than in those with less than 28.
4) HBe-antigen, -antibody seroconversion were found in 10 of 35 cases of chronic liver disease by serial follow up study. In six cases of them, seroconversion was detected over twice.
5) These seroconversion cases had following tendency. When HBs-antigen titer reached its peak, HBs-antigen appeared. After almost one month the serum transaminase level reached its peak. With the descend of the HBs-antigen titer and the transaminase level, the next seroconversion from HBe-antigen to HBe-antibody occured. The same pattern of HBe-antigen, -antibody seroconversion was recurred serially in same cases.
