Abstract
Higher cholinesterase activities than a normal level (2, 900-4, 500 U/1) were observed in 80 and 60% of 41 severe and 30 moderate cases of fatty liver which were classified by histological examination of the liver. The value was significantly higher in a severe group (a mean of 5, 311 U/l) than a moderate group (4, 748 U/1) (p<0.01), but was not related to an association of diabetes mellitus, obesity and habitual alcohol intake. The elevation was associated with significant elevations of serum lipids, albumin ahd γ-GTP. T 1/2 of 131 I-RISA in 13 severe cases was moderately shortened (7.0-10.2 days). An isozyme pattern of ChE was normal. Thus, an elevation of ChE in fatty liver most likely reflects an increased production of the enzyme in the liver as well as lipoproteins and albumin induced by abnormal lipid metabolism.
