Abstract
A 49 days-old male infant died of intracranial hemorrhage including both subdural and intracerebral hemorrhage three weeks after admission to the hospital.
At the autopsy, the liver was enlarged and its cut surface showed centrilobular greenish discoloration.
Microscopically, we observed centrilobular cholestasis and many multinucleated giant cells in intermediary and peripheral zone of liver lobules.
From these findings, we considered the following possibility:
The excess production of bilirubin, due to marked hemolysis after intracranial hemorrhage, disturbed the hepatocytes directly and transformed the hepatocytes into multinucleated giant cells. These transformed giant cells blocked the bile flow through the bile canaliculi.
Therefore, we concluded that the present case might be regarded as so called "inspissated bile syndrome" caused by intracranial hemorrhage.
The present report discusses the clinical course and pathogenesis of this syndrome.
