1981 Volume 22 Issue 9 Pages 1306-1311
HBV-M.G.N. caused by HBe antigen-antibody immune complex in infant, who are highly positive for HBe antigen, has been reported, but there is no report of adult cases. We experienced a 48-years-old male of HBs antigen positive chronic hepatitis associated with M.G.N. caused by HBe antigen-antibody immune complex. In the course of chronic hepatitis B, proteinuria was continuously positive (100-300mg/dl). Liver biopsy showed CAH (2A), and the finding by kidney biopsy was membranous glomerulonephritis (M.G.N.). Examinations of frozen tissue sections by fluoresceinantibody technic revealed deposition of HBe antigen, IgG and βIC on the glomerular basment membrane, but no HBs antigen. At that time, serological examination showed positive for serum HBe antigen by M.O.method, βIA in 62 mg/dl, and negative for immune complex in serum.
