肝UDP-glucuronyl transferase活性におよぼすグルカゴンの効果

竹崎 英一; 竹本 学; 盛生 宏一; 中西 敏夫; 吉川 正哉; 松浦 寿二郎; 折免 滋雄; 川本 広夫; 川上 広育; 梶山 梧郎

doi:10.2957/kanzo.23.1270

Effect of glucagon on UDP-glucuronyl transferase activity

Eiichi TAKEZAKI, Manabu TAKEMOTO, Koichi MORIO, Toshio NAKANISHI, Masaya KIKUKAWA, Toshijiro MATSUURA, Shigeo ORIME, Hiroo KAWAMOTO, Hiroiku KAWAKAMI, Goro KAJIYAMA

Author information

Eiichi TAKEZAKI
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Manabu TAKEMOTO
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Koichi MORIO
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Toshio NAKANISHI
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Masaya KIKUKAWA
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Toshijiro MATSUURA
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Shigeo ORIME
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Hiroo KAWAMOTO
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Hiroiku KAWAKAMI
Depertment of Internal Medicine, School of Medicine, Hiroshima University
Goro KAJIYAMA
Depertment of Internal Medicine, School of Medicine, Hiroshima University

Keywords: cyclic AMP, α-aaphthyl isothiocyanate(ANIT)

JOURNAL FREE ACCESS

1982 Volume 23 Issue 11 Pages 1270-1276

DOI https://doi.org/10.2957/kanzo.23.1270

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Abstract

We obserbed that uridine diphosphate glucuronyl transferase (UDP-GT) activity was a significant functional marker of hepatic reserve mass and that was a similar response between UDPGT activity and cyclic AMP by glucagon injection, glucagon tolerance test, in rats treated with alpha-naphthyl isothiocyanate (ANIT). Augmentation of UDP-GT activity was obtained by glucagon and dibutyryl cyclic AMP proportional to amount of liver cell injury and was inhibited by Actinomycin D, a known inhibitor of protein synthesis. There was indicated that cyclic AMP mediated glucuronyl transferase synthesis.

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