Kanzo
Online ISSN : 1881-3593
Print ISSN : 0451-4203
ISSN-L : 0451-4203
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Volume 23, Issue 11
Displaying 1-23 of 23 articles from this issue
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  • Hepatic tissue oxygenation during degeneration and regeneration of the liver in rats treated with carbon tetrachloride
    Takenobu KAMADA, Yutaka KISHIDA, Nobuhiro SATO, Haruya MEREN, Tsue Tgu ...
    1982 Volume 23 Issue 11 Pages 1249-1255
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1249
    JOURNAL FREE ACCESS
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    The hepatic tissue oxygenation during degeneration and regeneration of the liver was studied in carbon tetrachloride treated rats, using a newly developed tissue oxygen electrode and organ reflectance spectrophotometry. The respiratory activity of the liver slices was also measured in vitro in oxygen electrode apparatus. The results suggest that a decrease of respiratory activity initiates degeneration of liver cells, followed by disturbance of microcirculation and lowering of hepatic tissue oxygen tension. After 48 hours of carbon tetrachloride administration, the respiratory activity improved and the hepatic tissue oxygen tension increased slightly, which may initiate regeneration in accordance with improvement of hepatic microcirculation.
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  • A study on aldehyde dehydrogenase isozyme pattern in patients with alcoholic liver injury
    Harumasa YOSHIHARA, Nobuhiro SATO, Norio HAYASHI, Haruya MERE, Akinori ...
    1982 Volume 23 Issue 11 Pages 1256-1261
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1256
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    The relationship between the polymorphism of aldehyde dehydrogenase (ALDH) and alcoholic liver injury was studied by analyzing ALDH isozymes in hair roots and liver specimens from chronic alcoholics with liver injury using isoelectric focusing electrophoresis method. Among 27 chronic alcoholics with liver injury, low Km ALDH isozyme was positive in 25 cases (93%). The frequency was significantly higher than that in normal volunteers, 6 positive cases among 12 (50%). The pattern of low Km ALDH isozyme of liver specimens was coincided with that of hair roots, and all cases with low Km ALDH isozyme showed no facial flushing after drinking alcohol. Moreover, there was no difference in hepatic function between patients with and without low Km ALDH isozyme. It was concluded that low Km ALDH isozyme was detected in higher frequency in chronic alcoholics with liver injury than in normal volunteers.
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  • Clinical and experimental studies on hepatic mitochondrial enzymes in liver cirrhosis.
    Special reference to OCT and m-GOT acitvities
    Yoshihiro KUNITAKE
    1982 Volume 23 Issue 11 Pages 1262-1269
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1262
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    The significance of simultaneous assay of serum ornithine carbamyl transferase (s-OCT) and mitochondrial aspartate aminotransferase (m-GOT) was studied in patients with liver cirrhosis with or without hepatocellular carcinoma (HCC). Parallel elevation of s-OCT and m-GOT was observed in patients with acute and chronic hepatitis and OCT/m-GOT ratio was 1.22 in the former and 1.26 in the latter. However, predominant elevation of s-OCT was observed in patients with liver cirrhosis with or without HCC. This finding was more distinct in liver cirrhosis with hyperammonemia and in cirrhosis with HCC, and OCT/m-GOT ratio was up to 1.74 and 2.1 respectively. Assay of liver tissue concentration of these two enzymes revealed dominant activity of OCT in cirrhotic liver, however, those activities of HCC tissue were low and showed little OCT dominancy.
    Significant elevation (p<0.05) of s-OCT acitvity paralleling with increase of OCT activity in liver tissue was noted by loading of 80% casein (high protein diet) in the cirrhotic rats induced by CCl4, while in those fed with 25% casein (normal protein diet), no significant change of OCT was observed either in serum or in tissue.
    These results suggested followings:
    1) The predominant elevation of s-OCT and the increase of serum OCT/m-GOT ratio in liver cirrhosis indicate enzyme induction in urea cycle of the hepatocyte.
    2) The tendency of predominantly higher s-OCT activity in HCC with cirrhosis reflects the enzyme induction in cirrhotic liver.
    3) The increase of s-OCT/s-mGOT ratio in liver cirrhosis is suggestive of overload of nitrogen compounds and useful for prediction of hepatic encephalopathy.
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  • Effect of glucagon on UDP-glucuronyl transferase activity
    Eiichi TAKEZAKI, Manabu TAKEMOTO, Koichi MORIO, Toshio NAKANISHI, Masa ...
    1982 Volume 23 Issue 11 Pages 1270-1276
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1270
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    We obserbed that uridine diphosphate glucuronyl transferase (UDP-GT) activity was a significant functional marker of hepatic reserve mass and that was a similar response between UDPGT activity and cyclic AMP by glucagon injection, glucagon tolerance test, in rats treated with alpha-naphthyl isothiocyanate (ANIT). Augmentation of UDP-GT activity was obtained by glucagon and dibutyryl cyclic AMP proportional to amount of liver cell injury and was inhibited by Actinomycin D, a known inhibitor of protein synthesis. There was indicated that cyclic AMP mediated glucuronyl transferase synthesis.
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  • Identification of various intrahepatic antigens by a novel immunochemical method utilizing peroxidase-conjugated-protein A
    Osamu YOKOSUKA, Masao OMATA, Junko MORI, Katsuo UCHIUMI, Yoshimi ITO, ...
    1982 Volume 23 Issue 11 Pages 1277-1285
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1277
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    Protein A has a property to combine with Fc portion of IgG. Utilizing this character, HBsAg, HBcAg and α1-antitrypsin were successfully demonstrated in the liver tissue by the method of peroxidase-conjugated-protein A. Comparing to peroxidase-conjugated-IgG method (indirect immunoperoxidase method), the peroxidase-conjugated-protein A (Pa-Po) method has less nonspecific staining and as a result better contrast in revealing various intrahepatic antigens. As protein A is able to attach itself to Fc portion of IgG from various mammals, there is no need to use peroxidase-conjugated-anti-IgG to corresponding mammals, so Pa-Po method is a simpler and easily applicable immunochemical method to reveal various antigens in tissue.
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  • Membranous expression of HBsAg in liver and HBeAg/anti-HBe system in sera of HBsAg positive with chronic liver disease
    Gotaro YAMADA, Yuji SAKAMOTO, Motowo MIZUNO, Takashi NISHIHARA, Shingo ...
    1982 Volume 23 Issue 11 Pages 1286-1291
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1286
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    Fifty-eight patients with HBsAg-positive chronic liver disease were studied for membranous expression of HBsAg in liver by peroxidase labeled antibody method as well as for HBeAg/anti-HBe in sera by radioimmunoassay. Membranous pattern of HBsAg was demonstrated in 16 of 28 patients with HBeAg, in 5 of 16 patients with anti-HBe and in 4 of 14 patients with judge pended for HBeAg/anti-HBe. In serial sections, HBcAg-positive hepatocytes were observed in 6 of 13 patients with diffusely membranous HBsAg and in 9 of 12 patients with focally membranous HBsAg. Thirteen of 19 HBeAg-positive patients with chronic hepatitis had membranous expression of HBsAg, but one of 7 HBeAg-positive patients with liver cirrhosis had membranous HBsAg. Diffusely membranous expression of HBsAg was mostly observed in patients with stable level of SGPT and histological diagnosis of CAH 2A, and in contrast, focally membranous expression of HBsAg was often found in patients with high level of SGPT and histological diagnosis of CAH 2B.
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  • An epidemiological study of HBsAg and anti-HBs in medical personnel
    long term follow-up study
    Shosuke IWAMA, Kunihiko OHNISHI, Yukio NAKAJIMA, Masao OMATA, Toshiko ...
    1982 Volume 23 Issue 11 Pages 1292-1298
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1292
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    Medical personnel are at risk of contracting hepatitis B virus (HBV) infection. We measured annually HBsAg and anti-HBs in the employees of our hospital from 1975 to 1980 in order to estimate the frequency of natural HBV infection in medical personnel. The positivity of anti-HBs was the highest among laboratory technicians, followed by doctors, nurses and nurse aides, and the lowest in non-medical employees. The percentage of annual positive turn of anti-HBs was 2.6% in laboratory technicians, 2.0% in doctors, 1.4% in nurses and nurse aides, and 1.0% in others. None of them had clinical acute hepatitis and it was thought that most the positive turns were due to subclinical infection. However, during the six year period, three cases of acute hepatitis B occurred among medical staff. These results clearly indicated that the personnel who handle blood or come in close contact with patients are at high risk compared to non-medical staff, calling for more positive prophylactic measures.
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  • A study on the interaction between liver diseases and their therapeutic agents: Etiological factors in carbon tetrachloride induced hepatic necrosis and its prevention with anti-oxidant
    Kiwamu OKITA, Wakako TSUBOTA, Masako MIYAZAKI, Keijiro ANDO, Masa-aki ...
    1982 Volume 23 Issue 11 Pages 1299-1307
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1299
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    There are 2 kinds of etiological concept concerening carbon tetrachloride induced liver injury. That is, one is due to covalent binding of active metabolites of CCl4 to microsomal membrane, and another is due to lipid peroxidation based upon peroxidative decomposition of lipids on the membrane. In this experiment, cytochrome p-450, lipid peroxide (tissue and plasma), and lipids were determined through the experimental period. In conclusion, it was confirmed that lipid peroxide in the liver and sera increased remarkably after administration of CCl4 and pretreatment of r-oryzanol known as anti-oxidant blocked either production of lipid peroxide or the following hepatic necrosis. This result can support that the administration of anti-oxidants may be useful in the treatment of the liver diseases resulted from increased lipid peroxidation in the hepatocytes.
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  • Studies on the relating factors to the effects of the special amino acids infusion on hepatic encephalopathy
    Toshihiro MORIKAWA
    1982 Volume 23 Issue 11 Pages 1308-1314
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1308
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    The effects of the specific amino acids infusion therapy (applied 26 times) on hepatic en-cephalopathy were analysed. The number of patients who received the treatment was 16 (3 with fulminant hepatitis, 9 with liver cirrhosis and 4 with primary hepatoma). The effects were evaluated from the changes in the grades of coma.
    Encephalopathy improved in 21 out of 26 treatments (81%). The improved rates were 40% in fulminant hepatitis, 86% in liver cirrhosis and 100% in hepatoma. There was no significant relationship between the effects of treatment and sex, age, duration of the treatment or liver function tests, respectively.
    In patients who had participating factors for the development of encephalopathy, such as constipation, dehydration, alcohol ingestion, common cold and infusion of the commercial amino acids solution, effects of the treatment were prominent. On the other hand, the effects were slight in the patients with severe bleeding and were not effective in the patients with severe infection.
    The changes of the BCAA/AAA ratios and blood ammonia levels following the treatment were not correlated with the effects of the treatment.
    These results indicate that many factors may be related to the development of hepatic encephalopathy and that the revision of BCAA/AAA ratios may play a trigger action on the improvement of hepatic encephalopathy.
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  • Hepatic artery ligation for unresectable hepato-cellular carcinoma
    Review of 60 cases and long term follow-up results
    Eizo OKAMOTO, Nobutaka TANAKA, Naoki YAMANAKA, Keiji KUWATA
    1982 Volume 23 Issue 11 Pages 1315-1325
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1315
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    Hepatic artery ligation has been performed on 60 patients with unresectable hepato-cellular carcinoma in the period 1975-1981. The proper hepatic artery was ligated in 40 cases and either the left or right branch in others. Patients were divided into two groups. In group A (32 cases), the ischemic effect of hepatic artery ligation was expected to cover the whole lesions in the liver. In group B (28 cases), the effect was considered to be limited because of the extrahepatic spread of cancer and/or its distant metastasis.
    Operative death was occurred in 2 (6%) in group A, while 6 (21.4%) in group B. Main cause ofdeath was post-operative liver failure. 20 cases (66.7%) out of 30 cases in group A who had tolerated the operation survived for 6 months, 12 (40%) for 1 year, 6 (20%) for 2 years and 2 (6.6%) for more than 3 years. The last two patients are surviving now for more than 4.9 and 4.4 years respectively. Even in group B, 10 cases (45.5%) survived for 6 months and 4 cases (18.2%) survived for more than 1 year.
    In 12 cases of group A, postoperative AFP levels fell rapidly with a half life of less than 4 days, and returned to normal range in 11 cases, 9 of them are still surviving. The liver cirrhosis was not a factor of contraindication as far as it was in a compensatory stage. Tumor thrombus obstructing the main portal vein branch was not the indication of this procedure, especially in cases associated with massive A-P shunt.
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  • Clinical studies on two cases of hepatic angiosarcoma
    Shu MIYAKE, Kimiaki ONOUE, Masatoshi UEDA, Hiroshi KOHNO, Fumio ARAKI, ...
    1982 Volume 23 Issue 11 Pages 1326-1333
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1326
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    Hepatic angiosarcoma (HAS) is a malignant tumor which originates in hepatic vascular system and it is known to be a very rare disease. We report two cases of HAS.
    A 59 year-old official girl (case 1), who was bombed in Hiroshima at her age of 23, was admitted to our hospital with chief complaint of general malaise, fever and epigastralgia. She had hepatomegaly and her laboratory studies disclosed elevated serum GOT/GPT activity ratios, elevated serum ferritin levels and thrombocytopenia. She died in six months after the onset and diagnosed as HAS with liver cirrhosis on autopsy.
    Case 2 is a 65 year-old housewife, who was admitted with chief complaint of right hypochondralgia and meteorism. Her physical examination revealed hepatomegaly and her laboratory studies showed elevated serum GOT/GPT activity ratios. She died in three months after the onset of her symptoms. Autopsy disclosed HAS without liver cirrhosis.
    These two cases had no relations with thorotrast, vinyl chloride etc., although there might be some influence of an atomic bomb on case 1. We could diagnose the above two cases only by autopsy. So, we must make efforts to diagnose at an early stage with angiography, peritoneoscopic examination, open liver biopsy and so on, which are reportedly to be helpful measures to diagnose HAS.
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  • The effect of phenobarbital on bile acids and bilirubin in two patients with prolonged severe intrahepatic cholestasis
    Hironao KOMATSU, Satoshi MONNO, Yukio GIBO, Yoshihiro AKAHANE, Kendo K ...
    1982 Volume 23 Issue 11 Pages 1334-1341
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1334
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    We reported two patients of prolonged severe intrahepatic cholestasis who showed a rapid response to the phenobarbital (PB) administration, followed with the disappearance of jaundice.
    Case 1, 27-year-old male, and case 2, 22-year-old female, were admitted to our department because of severe jaundice and pruritus of long duration. Glucocorticoid therapy for 100 and 190 days was not effective in both cases.
    In case 1, after three months of PB (3mg per kg of body weight per day) treatment, total serum bile acids concentration (TBA) decreased from 140μMol/l to 7.9μMol/l and total serum bilirubin level (T. Bil) from 30mg/dl to 0.7mg/dl.
    In case 2, after about fifty days of PB (2mg per kg of body weight per day) TAB decreased from 270μMol/l to 14.6μMol/l and T. Bil from 35.8mg/dl to 1.8mg/dl.
    PB was very effective in relieving the pruritus and decreasing the jaundice. The mechanism of the therapeutic effect of PB on prolonged intrahepatic cholestasis was discussed.
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  • Tiopronin hepatotoxicity
    A report of two cases, including review of the literature
    Takumi ARAMAKI, Hidemasa OKUMURA, Kazuhiro OKANO, Yukio UEDA, Kazuteru ...
    1982 Volume 23 Issue 11 Pages 1342-1347
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1342
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    Two cases of Tiopronin hepatotoxicity are described, one in a 62-year-old female and the other in a 27-year-old male.
    In the first case, the patient was treated with Tiopronin for eczema and developed malaise, pruritus and jaundice after 20 days of medication. In the second case, general malaise developed after 25 days of Tiopronin treatment for liver disease. In both cases there was marked elevation of theserum biliary enzymes, and lymphocyte stimulation tests with Tiopronin revealed positive results. Biopsies of the liver revealed the residua of parenchymal inflammation, although fibrosis and mononuclear cell infiltration were also found in the enlarged portal area in the second case. This was evaluated as pre-existing chronic persistent hepatitis.
    The clinical and histological characteristics of Tiopronin hepatotoxicity in these two cases and 8 others reported in the literature are reviewed. BSP hepatotoxicity, which complicated the first case, is also covered in a brief review which additionally includes three other cases reported previoualy.
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  • [title in Japanese]
    [in Japanese], Yunus Tanggo, [in Japanese], [in Japanese], [in Japanes ...
    1982 Volume 23 Issue 11 Pages 1348
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1348
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 23 Issue 11 Pages 1349
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1349
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1350
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1350
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1351
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1351
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1352
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1352
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1353
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1353
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1354
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1354
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese]
    1982 Volume 23 Issue 11 Pages 1355
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1355
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    [in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...
    1982 Volume 23 Issue 11 Pages 1356
    Published: November 25, 1982
    Released on J-STAGE: July 09, 2009
    DOIhttps://doi.org/10.2957/kanzo.23.1356
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1982 Volume 23 Issue 11 Pages 1357-1382
    Published: November 25, 1982
    Released on J-STAGE: January 19, 2010
    DOIhttps://doi.org/10.2957/kanzo.23.1357
    JOURNAL FREE ACCESS
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