Abstract
A male case of lupoid hepatitis associated with stomach cancer was presented. The patient was a 48-year-old male, who visited our hospital because of polyarthralgia and lassitude lasting for 3 months. Laboratory examination revealed hypergammaglobulinemia (6.6g/dl), hypocomplementemia and positive LE cell phenomenon with many autoantibodies including ANF, anti-DNA, anti-globulin, anti-insulin and anti-lymphocyte. However, HBs antigen and anti-smooth muscle antibody were negative. Cellular immunity was depressed and HLA typing was A2, AW24, BW52, BW46, CW1, CW3, DR2, En. Liver biopsy specimens showed massive lymphoid infiltrations in enlarged portal tracts with regenerating hepatocytes forming rosettes in periportal areas presenting the figure of liver cirrhosis with chronic active hepatitis. Advanced stomach cancer, tubular adenocarcinoma histologically, was revealed by the examination of upper G-I tract. Male cases of lupoid hepatitis are rare in Japan and the association of lupoid hepatitis with malignancy has been discussed.
