1983 Volume 24 Issue 12 Pages 1424-1428
The 14-year-old girl presented with a 5 month history of amenorrhea. She developed jaundice and was hospitalized elsewhere. She was treated as acute hepatitis.
The persistence of severe biochemical liver function tests led her to consult to the Kyoto University Hospital. Physical examination results revealed mild jaundice and anemia. Laboratory findings included hemoglobin of 7.9g/dl, reticulocyte count of 96‰, serum total bilirubin of 3.3mg/dl, senlm copper of 102μg/dl and serum concentration of heptoglobin of 18mg/dl. Coomb's test was negative. The diagnosis of Wilson's disease was confirmed by a low serum ceruloplasmin, high liver and urinary copper values and a presence of Kayser-Fleischer rings. Hypothalamic lesion was suspected according to LH-RH and clomiphene tests.
After 7 months of D-penicillamine treatment, her hemoglobin returned to normal and her serum albumin concentration increased from 2.8 to 4.9g/dl. Reapperance of her menstruation occured after 7 months of treatment.
