A morphological study on interlobular bile duct lesions in acute viral hepatitis
A pathological study by electron microscope
1983 Volume 24 Issue 6 Pages 598-607
Details
1983 Volume 24 Issue 6 Pages 598-607
In this study, interlobular bile ducts and bile ductules observed in 18 specimens from 17 cases with acute viral hepatitis were investigated by electron microscope.
In most bile ducts seen intact under light microscope "dark cell" and/or "light cell" metamorphosis of bile duct epithelium were observed. Defective basement membrane were observed in the bile ducts where the "dark cell" had spilled out from the basal side and severe cell infiltration occurred only in the specimens of hepatitis A. The organelles exhibited no remarkable changes and the relationship between pinocytotic vesicles and cell infiltration into or around the bile ducts was not apparent. A specific finding with hepatitis A was that macrophages infiltlrated the bile ducts. Virus-like particles were observed in the lysosome of the macrophage which infiltrated the bile duct of a patient with hepatitis A.
