A morphological study on interlobular bile duct lesions in acute viral hepatitis

A clinicopathological study by light microscope

Abstract

In this study, interlobular bile ducts observed in 55 biopsy specimens taken from 48 patients with acute viral hepatitis on 47.6±17.9 days after onset were investigated.
The incidence of bile duct lesions was, in order of occurrence, Cell Vacuolation, Nuclear Pleomorphism, Cell Swelling, Karyorrhexis, Nuclear Hyperchromatism, Inflammatory Cells, and Stratification. Bile duct lesions were observed in 18% of all biopsy specimens, and the incidence rate was hepatitis A (26%), non-A, non-B (19%), and B (10%). There was no apparent correlation between bile duct lesion types and the types of acute viral hepatitis. In the specimens taken within 26 days after the disappearance of jaundice, the incidence of bile thrombi was higher (p<0.05) in hepatitis A than in hepatitis B. The relationship between bile duct lesions and bile thrombi was not apparent, and the significance of bile duct lesions has not yet been clarified.