1983 Volume 24 Issue 6 Pages 654-658
A 16 year-old boy was found to have elevated levels of serum transaminases in the screening test of blood donor. He was asymptomatic and family history was negative for liver or neuropsychiatric disorder.
Further examination disclosed a characteristic feature of copper metabolism to Wilson's disease: hypocupremia, hypoceruloplasminemia and increased urinary excretion of copper. But Kayser Fleischer ring and extrapyramidal symptoms were not recognized. The histology of liver consisted with chronic active hepatitis with fatty metamorphosis and glycogen nuclei. Copper concentration was high as 1025μg per gram dry liver weight. A final diagnosis of asymptomatic Wilson's disease was made and D-penicillamine therapy was instituted uneventfully.
