1984 Volume 25 Issue 12 Pages 1522-1526
Serial studies on e antigen-positive chromic hepatitis type B have revealed reappearance of e antigen after serocovension from e antigen to e antibody. Ninety four patients who were e antigen-positive initially, were followed for 54 months. Thirty nine of 94 patients (41.5%) have had e antigen continuously, 28 patients (29.8%) have shown seroconversion from e antigen to e antibody. Reappearance of e antigen after seroconvension (reversed seroconvension) were observed in 5 of 94 patients (5.3%). Twenty of 94 patients (21.3%) lost e antigen, reappeared without appearance of e antibody.
These 25 cases who demonstrated reappearance after loss of e antigen contained only one female, and male was significantly dominant (p<0.05).
Reversed seroconversion occurred in cases of chronic aggressive hepatitis IIb and liver cirrhosis all but one chronic aggressive hepatitis IIa.
