Abstract
Hepatic contents of hydroxyproline (Hyp) and hydroxylysine (Hyl) were assayed in patients with and without liver diseases. Hepatic contents of Hyp and Hyl in normal liver were 4.2±0.5 and 0.4±0.1μmol/g liver, respectively. In patients with liver diseases, hepatic contents of Hyp and Hyl were increased proportionally with the progress of hepatic fibrosis. Percentage of the interstitial collagen calculated from Hyl/Hyp ratio was about 81% in normal liver and was not so changed in fibrotic liver. These results suggest that there may be almost no differences in the proportion of the interstitial and basement membrane collagen between normal and fibrotic liver.
