Abstract
The long term result of Eck is unsatisfactory. Death due to hemorrhage is often replaced by postshunt liver failure or portasystemic encephalopathy. Therefore, I attempted to elucidate the effect of portal blood diversion on the liver and pancreatic endocrine function. Eck were performed in 8 mongrel dogs. The liver tissue in the Eck had lower concentration of glycogen and cyclic AMP than in the control. After arginine infusion, Eck had higher portal IRG and lower portal IRI concentrations than the control. But portal glucose concentration did not change in the control and Eck. In amino acid analysis, Fischer's ratio, Eck 1.0, control 3.5. But arginine and alanine were within normal limit. It was concluded that the lower concentration of glycogen in liver tissue in Eck influenced pancreatic endocrine function to maintain blood sugar level, as a result, hyperglucagonemia and hypoinsulinemia in portal blood was showed.
