1986 Volume 27 Issue 9 Pages 1281-1289
Age-specific incidence rates of hepatocellular carcinoma (HCC) in Japan (1980) were estimated by sex, HBsAg status and drinking history, using existing population-based data. Based on them, relative risk and cumulative risk of HCC (30 to 74 years old) were investigated.
1) The incidence rates of HCC among HBsAg carriers increased exponentially with age from the thirties to the former half of the forties in both sexes. Thereafter the ratio of increase slowed down and ceased.
2) For male carriers aged 30-44 years, the relative risk for HCC was about one hundred. Such a high relative risk was also shown for female carriers aged 30-49 years.
3) The cumulative risk of HCC was 20% for male carriers, and 5.6% for female carriers. Meanwhile, it was 1.7% for male non-carriers and 0.45% for female non-carriers.
4) The male non-carriers' cumulative risk was 5.0% for drinkers and 1.2% for non-drinkers. The male carriers' risk was 40% for drinkers and 16% for non-drinkers.
