Abstract
In order to prevent HB virus infection, 407 persons of medical staff who received accidental HBV exposure such as needle stick, blood on cut, suture needle stick and so on, were adminiStered HB globulin (HBIG). Two of them merely developed acute hepatitis (type B). Thereafter, we administered HB-vaccine three times againSt 596 persons with neither HBsAg nor anti-HBs. Out of them, 533 persons (89.4%) acquired anti-HBs. Moreover, we carried out the study of prevention for maternal transmission of HBV by combined use of HB vaccine and/or HBIG. Compared that 57 out of 67 infants (85.1%) born to HBeAg pOsitive carrier mothers became HBV carrier without treatment, 4 out of 75 infants (5.3%) merely became HBV carrier.
These results indicated that HBIG and HBvaccine administration was extremely effective for the prevention of accidental and perinatal transmission of HBV.
