1987 Volume 28 Issue 12 Pages 1558-1567
The serum Cu, Zn-SOD concentration and histological localization in patients with HCC, LC, and alcoholic liver injury were examined.
The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared to healthy adults and also patients with LC.
In about 20% of our specimens, tumors were strongly stained in comparison with the surrounding tissue.
The main histological characteristic of LC was that Cu, Zn-SOD localized more in hepatocytes bordering on the connective tissue in the pseudolobular of some specimens. There was a tendency that this characteristic was more often in A and A' types than other types.
In alcoholic liver injury, there were 3 Cu, Zn-SOD stain patterns such as "Diffuse Type", "Granular Type", and "Nuclear Type". There was a tendency for the specimens from heavy drinkers to be "Granular Type".
These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and also to be a parameter for liver damage in chronic liver disease.
