A case of primary hepatic lymphoma with cirrhosis of the liver

Abstract

A 55-year-old woman was pointed out abnormal liver function tests in July 1979 and a diagnosis of chronic hepatitis (non B) was established. ^99mTc-Scintigram showed a space occupying lesion in the right lobe of the liver in August 1982. Physical examination revealed hepatomegaly. Liver function tests showed high values of a lactic dehydrogenase (1088mIu/ml) and a ferritin (300ng/ml). The imaging diagnoses demonstrated hepatocellular carcinoma with cirrhosis of the liver. Although she was treated with the immunochemotherapy, she died of hepatic failure in March 1983. The autopsy disclosed cirrhosis of the liver (Z type) and a large yellowish gray tumor (14×10×8cm). Microscopic findings of the tumor showed tumor cells were separated to each other. The electron microscopy and the peroxidase antiperoxidase method diagnosed the case as primary hepatic lymphoma, which was diffuse lymphoma of the large cell type (non-cleaved, B cell) in the Lymphoma Study Group.