D-galactosamine障害肝ラットに対するdibutyryl cyclic AMPとグルカゴンによる糖代謝への影響

松尾 行雄; 竹崎 英一; 末盛 彰一; 小松 晃一; 田村 徹; 天野 始; 舛田 一成; 中村 利夫; 森石 真吾; 中山 茂; 池本 吉博; 渡辺 恭行; 吉川 正哉; 中西 敏夫; 梶山 梧朗

doi:10.2957/kanzo.29.329

Effect of dibutyryl cyclic AMP and glucagon on carbohydrate metabolism in rats with D-galactosamine induced hepatitis

Yukio MATSUO, Eiichi TAKEZAKI, Shoichi SUEMORI, Kouichi KOMATSU, Touru TAMURA, Hagime AMANO, Kazunari MASUDA, Toshio NAKAMURA, Shingo MORIISHI, Shigeru NAKAYAMA, Yoshihiro IKEMOTO, Yasuyuki WATANABE, Masaya KIKKAWA, Toshio NAKANISHI, Goro KAJIYAMA

Author information

Yukio MATSUO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Eiichi TAKEZAKI
Internal Medicine, National Kure Hospital
Shoichi SUEMORI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Kouichi KOMATSU
The First Department of Internal Medicine, Hiroshima University School of Medicine
Touru TAMURA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Hagime AMANO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Kazunari MASUDA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Toshio NAKAMURA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Shingo MORIISHI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Shigeru NAKAYAMA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Yoshihiro IKEMOTO
The First Department of Internal Medicine, Hiroshima University School of Medicine
Yasuyuki WATANABE
The First Department of Internal Medicine, Hiroshima University School of Medicine
Masaya KIKKAWA
The First Department of Internal Medicine, Hiroshima University School of Medicine
Toshio NAKANISHI
The First Department of Internal Medicine, Hiroshima University School of Medicine
Goro KAJIYAMA
The First Department of Internal Medicine, Hiroshima University School of Medicine

Keywords: dibutyryl cyclic AMP, D-galactosamine

JOURNAL FREE ACCESS

1988 Volume 29 Issue 3 Pages 329-335

DOI https://doi.org/10.2957/kanzo.29.329

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Abstract

Comparative study of the effect of dibutyryl cyclic AMP (DBcAMP) and glucagon on carbohydrate metabolism was carried out in rats with D-galactosamine (GalN) induced hepatitis.
It was showed that DBcAMP was more effective on gluconeogenesis than that glucagon. On the contrary, it was showed that glucagon was more effective on glycogenolysis than that DBcAMP, suggesting the different mechanism between DBcAMP and glucagon on carbohydrate metabolism in GalN treated rats.
These data suggest the effects of DBcAMP on the prevention of disturbance of hepatic carbohydrate and energy metabolism in rats with GalN induced hepatitis.

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