A case report of non-alcoholic steatohepatitis associated with tiopronin-induced liver injury

Abstract

A 43-year-old man with non-alcoholic steatohepatitis was reported. He had no history of heavy drinking and showed liver dysfunction compatible with fatty liver. The laboratory data turned for the worse and he received tiopronin at a practitioner. Two months later sever intrahepatic cholestasis was appeard and continued for four months. Laparoscopy and liver biopsy were done and the liver histology showed centriloblar inflammation, fibrosis and Mallory bodies predominantly in zone 3. This findings were compatible to the histology of alcoholic hepatitis. We diagnosed this case as non-alcoholic steatohepatitis associated with tiopronin induced liver injury.