Abstract
The authors designed the chromosome studies on patients with the cleft lip and-palate to investigate its pathogenesis. On 100 patients of 25 cleft prepalate, 50 cleft prepalate and-palate and 25 cleft palate, chromosome studies were carried out by cultured peripheral blood leukocytes using a slight modification of the technique of Moorhead, et al. Out of 100 patients, 5 cases showed numeral or structural chromosome aberration ; one case D/E translocation, one case long No.1 chromosome, one case partial C trisomy (familial C/G transmission) and two cases 21 trisomy. And nine of the 55 male patients, consisted of 5 cases of cleft prepalate and 4 cases of cleft prepalate and palate patients had long Y sex chromosome. It is extremely interesting that 13 cases of the 14 patients with abnormal karyotype had the cleft of prepalate or its combined cleft in its cleft type.
