Dental implants are a very effective and useful treatment for the reconstruction of occlusions. For a successful treatment outcome, high-quality bone is required. Osteoblasts and marrow adipocytes come from common progenitor cells known as the bone marrow mesenchymal stem cell. During aging, and in some pathological conditions such as osteoporosis, the balance of osteoblastogenesis and adipogenesis in the bone marrow mesenchymal stem cell population is disrupted such that adipogenesis is increased with respect to osteoblastogenesis, consequently resulting in decreased bone mass. Although the molecular mechanisms controlling the balance between osteoblastogenesis and adipogenesis in adult bone are of great interest, the exact nature of the signals regulating this process remains to be determined. Recently, we reported the mechanisms by which BMP3, a bone morphogenetic protein, 3 and TLE3, a transcriptional cofactor, suppress osteoblastogenesis and enhance adipogenesis of bone marrow mesenchymal stem cells. Taken together, these studies suggested that reduced expression or activity of BMP3 or TLE3 might establish novel methods to maintain and reconstruct high-quality bone in a therapeutic setting.
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