Abstract
Cancer chemotherapy used in the management of neoplastic lesions is important method along with surgical therapy and radiation therapy. Anatomical functional and cosmetic considerations make chemotherapy for oral cancer more important. However, the cytocidal effect of anti-cancer agents works not only on the tumor cells but also on the normal cells and tissues, and involves rather extensive specific sideeffects because of their toxicity. For this reason attempts have been made to minimize the systemic toxicity of anti-cancer agents on normal tissues and to uptake the maximum concentration in tumor areas. Based on these ideas, Klopp et al (1950) first introduced the intra-arterial infusion of anti-cancer agents. In treating oral cancers in our department since 1964, we have been treating the therapeutic plan as a first choice, in which regional intra-arterial infusion of various anti-cancer agents through the superfacial temporal artery. Accordingly, we belive that regional intra-arterial infusion therapy is beneficial to adjuvant chemotherapy for oral cancer.
